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The COVID-19 pandemic provided the opportunity for unprecedented access to national electronic health record data for research in secure data environments. At the same time, there has a been a push to develop regional secure data environments that contain the granular information collected more locally. Jonathan Sterne, Rachel Denholm and Venexia Walker co-lead a team of researchers at the University of Bristol who have worked within these environments. During this seminar, Rachel and Venexia will share their learnings and future directions for research using these resources.